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Angel Brown
Angel Brown

The Peripheral


Wilf's world is mysterious, full of extrapolated tech (wearable, implanted, assembler-based and sticky), rented bodies called "peripherals," and has been de-populated by an event called "the jackpot."




The Peripheral


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The endoplasmic reticulum (ER) consists of the nuclear envelope and a peripheral network of tubules and membrane sheets. The tubules are shaped by the curvature-stabilizing proteins reticulons and DP1/Yop1p, but how the sheets are formed is unclear. Here, we identify several sheet-enriched membrane proteins in the mammalian ER, including proteins that translocate and modify newly synthesized polypeptides, as well as coiled-coil membrane proteins that are highly upregulated in cells with proliferated ER sheets, all of which are localized by membrane-bound polysomes. These results indicate that sheets and tubules correspond to rough and smooth ER, respectively. One of the coiled-coil proteins, Climp63, serves as a "luminal ER spacer" and forms sheets when overexpressed. More universally, however, sheet formation appears to involve the reticulons and DP1/Yop1p, which localize to sheet edges and whose abundance determines the ratio of sheets to tubules. These proteins may generate sheets by stabilizing the high curvature of edges.


The peripheral nervous and immune systems are traditionally thought of as serving separate functions. The line between them is, however, becoming increasingly blurred by new insights into neurogenic inflammation. Nociceptor neurons possess many of the same molecular recognition pathways for danger as immune cells, and, in response to danger, the peripheral nervous system directly communicates with the immune system, forming an integrated protective mechanism. The dense innervation network of sensory and autonomic fibers in peripheral tissues and high speed of neural transduction allows rapid local and systemic neurogenic modulation of immunity. Peripheral neurons also seem to contribute to immune dysfunction in autoimmune and allergic diseases. Therefore, understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology.


Peripheral neuropathy is an umbrella term for nerve diseases that affect a specific subdivision of your nervous system. Many different conditions can cause peripheral neuropathy, which means a wide range of symptoms is also possible. Peripheral neuropathy can also affect different body parts, depending on how and why it happens.


Your nervous system has two parts, the central nervous system and the peripheral nervous system. Your brain and spinal cord are the two components that make up your central nervous system. Your peripheral nervous system consists of all the other nerves in your body. It also includes nerves that travel from your spinal cord and brain to supply your face and the rest of your body.


Peripheral neuropathy can affect anyone, regardless of age, sex, race or ethnicity, personal circumstances, medical history, etc. However, some people are at greater risk for specific types of peripheral neuropathy (see below under Causes and Symptoms for more about this).


Peripheral neuropathy is common, partly because this term refers to so many conditions. About 2.4% of people globally have a form of peripheral neuropathy. Among people 45 and older, that percentage rises to between 5% and 7%.


To understand how peripheral neuropathy affects your body, it helps to know a little about the structure of neurons, a key type of cell that makes up your nerves. Neurons send and relay signals through your nervous system using electrical and chemical signals. Each neuron consists of the following:


How peripheral neuropathy develops, particularly the timeline of its progress, depends very much on what causes it. Injuries can cause it to develop instantaneously or within minutes or hours. Some toxic and inflammation-based forms of peripheral neuropathy may develop rapidly over days or weeks, while most other conditions take months, years or even decades to develop.


There are many different symptoms of peripheral neuropathy. This condition can affect a single nerve, a connected group of related nerves, or many nerves in multiple places throughout your body. The symptoms also depend on the type of nerve signals affected, and multiple signal types may be involved.


Your peripheral nervous system carries motor signals, which are commands sent from your brain to your muscles. These signals are what make it possible for you to move around. Your muscles need nerve connections to the brain to stay healthy and work properly.


Your peripheral nerves convert information about the outside world into nerve signals. Those signals then travel to your brain, which processes those signals into what you can sense of the world around you. Peripheral neuropathy can disrupt what your senses pick up from the outside world or the ability of those senses to communicate with your brain.


The treatment for peripheral neuropathy can vary widely depending on its cause. Other factors can also affect treatment, including your medical history, personal preferences and more. Your healthcare provider is the best person to tell you more about the treatment(s) they recommend and the likely recovery timeline. In general, the following treatment methods are more common for peripheral neuropathy:


The possible side effects and complications of treatments for peripheral neuropathy depend on many factors. These include the specific cause of the neuropathy, other conditions you have, the specific treatments you receive and more. Your healthcare provider is the best person to tell you more about the possible side effects and complications you might experience.


Some of the possible causes of peripheral neuropathy are preventable. You can also lower your chances of developing it by preventing or delaying certain conditions. In general, the best preventive or precautionary steps you can take include:


The effects of peripheral neuropathy depend on the cause, the nerves it affects, your medical history, treatments you receive and more. Your healthcare provider is the best person to tell you more about what you can expect in your case.


If you have symptoms of peripheral neuropathy, you should see a healthcare provider as soon as possible. In some cases, peripheral neuropathy symptoms start before the condition causes permanent changes or damage, so it may be possible to limit the effects or even reverse them.


If you receive a diagnosis of peripheral neuropathy, you should see your healthcare provider as recommended or if you notice changes in your symptoms. You should also talk to them if you experience side effects from any treatments. Talking to your healthcare provider can be especially helpful when you have symptom changes or side effects that affect your usual routine and activities. Your provider may be able to modify your treatment or find ways to adapt to these changes and limit their effects.


Peripheral neuropathy is an umbrella term for any condition, disease or disorder that affects your peripheral nerves, which are all the nerves outside of your spinal cord and brain. There are many different ways that peripheral neuropathy can happen, so this condition is common.


The peripheral nervous system consists of the nerves that branch out from the brain and spinal cord. These nerves form the communication network between the CNS and the body parts. The peripheral nervous system is further subdivided into the somatic nervous system and the autonomic nervous system. The somatic nervous system consists of nerves that go to the skin and muscles and is involved in conscious activities. The autonomic nervous system consists of nerves that connect the CNS to the visceral organs such as the heart, stomach, and intestines. It mediates unconscious activities.


Each large axon is surrounded by oligodendrocytes in the brain and spinal cord and by Schwann cells in the peripheral nervous system. The membranes of these cells consist of a fat (lipoprotein) called myelin. The membranes are wrapped tightly around the axon, forming a multilayered sheath. This myelin sheath resembles insulation, such as that around an electrical wire. Nerve impulses travel much faster in nerves with a myelin sheath than in those without one.


One nerve (mononeuropathy Mononeuropathy Mononeuropathy is damage to a single peripheral nerve. Pressure on a nerve for a long time is the most common cause of mononeuropathy. The affected area may tingle, feel prickly, or be numb... read more )


Two or more peripheral nerves in separate areas of the body (multiple mononeuropathy Multiple Mononeuropathy Multiple mononeuropathy is the simultaneous malfunction of two or more peripheral nerves in separate areas of the body. It causes abnormal sensations and weakness. (See also Overview of the... read more )


Many nerves throughout the body but usually in about the same areas on both sides of the body (polyneuropathy Polyneuropathy Polyneuropathy is the simultaneous malfunction of many peripheral nerves throughout the body. Infections, toxins, drugs, cancers, nutritional deficiencies, diabetes, autoimmune disorders, and... read more )


A spinal nerve root Cranial nerves and spinal nerves The peripheral nervous system consists of more than 100 billion nerve cells (neurons) that run throughout the body like strings, making connections with the brain, other parts of the body, and... read more (the part of the spinal nerve connected to the spinal cord)


Certain disorders cause progressive deterioration of the nerve cells in the spinal cord and brain that control muscle movement (motor neuron diseases Amyotrophic Lateral Sclerosis (ALS) and Other Motor Neuron Diseases (MNDs) Motor neuron diseases are characterized by progressive deterioration of the nerve cells that initiate muscle movement. As a result, the muscles stimulated by these nerves deteriorate, become... read more ) as well as in the peripheral nerves. Motor neuron diseases can resemble peripheral nerve disorders, which affect nerve cells outside the brain and spinal cord rather than those in the spinal cord or brain. Motor neuron diseases may be caused by viruses (such as the polio Polio Polio is a highly contagious, sometimes fatal enterovirus infection that affects nerves and can cause permanent muscle weakness, paralysis, and other symptoms. Polio is caused by a virus and... read more virus), be inherited, or have no clear known cause (such as amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis (ALS) and Other Motor Neuron Diseases (MNDs) Motor neuron diseases are characterized by progressive deterioration of the nerve cells that initiate muscle movement. As a result, the muscles stimulated by these nerves deteriorate, become... read more ). 041b061a72


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